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QSARs of aromatic amines: identification of potent carcinogens

Rainer Franke1, Andreas Gruska, Cecilia Bossa

  • 1Consulting in Drug Design GbR, Gartenweg 14, D-16348 Wandlitz OT Basdorf, Germany.

Mutation Research
|July 6, 2010
PubMed

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Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
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