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Related Experiment Videos

[Hypertension treated with isotetrandrine].

H Y Dong1, C Yao

  • 1Hospital of Guiyang Medical College.

Zhong Xi Yi Jie He Za Zhi = Chinese Journal of Modern Developments in Traditional Medicine
|February 1, 1991
PubMed
Summary

Isotetrandrine (IT) effectively lowers blood pressure in mild to moderate hypertension, showing comparable results to nitrendipine (NTP). This study highlights IT

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Area of Science:

  • Pharmacology
  • Cardiovascular Medicine

Background:

  • Hypertension is a prevalent cardiovascular disease.
  • Isotetrandrine (IT) is a potential antihypertensive agent.
  • Nitrendipine (NTP) is a standard treatment for hypertension.

Purpose of the Study:

  • To evaluate the antihypertensive efficacy and safety of isotetrandrine (IT).
  • To compare the effects of IT with nitrendipine (NTP) in hypertensive patients.

Main Methods:

  • A cross-over study involving 50 patients with mild to moderate hypertension.
  • Administration of single-dose 0.2 g IT and daily doses of 0.3-0.6 g IT for 4 weeks.
  • Comparison with nitrendipine (NTP) as a control.

Main Results:

  • Isotetrandrine (IT) demonstrated definite antihypertensive effects across different hypertension phases.
  • A single dose of 0.2 g IT reduced blood pressure within 30 minutes, with maximal effect at 4 hours and sustained action for 8 hours.
  • The total response rate with daily IT doses was 84%, not significantly different from NTP.
  • IT treatment led to slight heart rate decrease, improved left ventricular function, and fewer/milder adverse effects, without influencing blood lipids or glucose.

Conclusions:

  • Isotetrandrine (IT) is an effective antihypertensive agent with a favorable safety profile.
  • IT's mechanism may involve calcium channel blockade.
  • IT offers a viable alternative for managing mild to moderate hypertension.

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