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Biomarkers in asthma and allergic rhinitis
Z Diamant1, J D Boot, E Mantzouranis
1Erasmus Medical Center, Depts. of Allergology and Pulmonology, P. O. Box 2400, 3000 CA Rotterdam, The Netherlands. z.diamant@gems.demon.nl
Pulmonary Pharmacology & Therapeutics
|July 6, 2010
Summary
Biological markers (biomarkers) indicate disease processes and treatment responses. Non-invasive biomarkers for asthma and allergic rhinitis aid diagnosis and monitoring, especially in children, with ongoing development for broader applications.
Area of Science:
- Biomarkers in Respiratory Medicine
- Clinical Diagnostics and Therapeutics
Background:
- Biological markers (biomarkers) are crucial indicators of biological processes and therapeutic responses.
- Applicable biomarkers require clinical relevance, sensitivity, specificity, and responsiveness to treatment.
- Non-invasive or semi-invasive airway sampling methods yield several biomarkers for asthma and allergic rhinitis.
Purpose of the Study:
- To explore the utility of biomarkers in diagnosing, staging, and monitoring asthma and allergic rhinitis.
- To highlight the value of reliable, non-invasive biomarkers, particularly for pediatric populations.
- To discuss the role of biomarkers in predicting and monitoring drug efficacy in early development.
Main Methods:
- Review of existing non-invasive and semi-invasive airway sampling techniques for biomarker identification.
- Assessment of biomarker characteristics including clinical relevance, reliability, and repeatability.
- Consideration of the heterogeneous nature of inflammatory responses in selecting appropriate biomarkers.
Main Results:
- Biomarkers offer complementary information to conventional diagnostic methods like spirometry.
- Biomarkers can aid in establishing diagnosis, monitoring disease activity, and predicting treatment response.
- Current biomarker techniques may require further validation and are not always suitable for very young children.
Conclusions:
- Biomarkers are increasingly vital in clinical practice and drug development for asthma and allergic rhinitis.
- Careful selection of biomarkers is essential, considering the target population and disease heterogeneity.
- Future advancements in sampling and quantification techniques, including 'omics' and imaging, will enhance biomarker detection and application.
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