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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
Long-term follow-up study of clear cell papulosis
Fang-Wen Tseng1, Tseng-Tong Kuo, Pei-Hsuan Lu
1Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Background:
Clear cell papulosis (CCP) was described as a new entity in 1987. Since then, only case reports or small case series have appeared in the literature and the long-term outcome of CCP remains unknown.
Objectives:
The aim of this study was to review cases of CCP diagnosed at our institution and to investigate their outcome.
Methods:
Nineteen patients given a diagnosis of CCP more than 6 years previously were identified. Their medical records and histopathologic findings were reviewed.
Results:
With a median follow-up duration of 11.5 years, regression of skin lesions was observed in 85.7% of patients. Persistence of skin lesions 11.5 years after diagnosis was confirmed histopathologically in one case, with a reduction in clear cell density.
Limitations:
Retrospective nature of the study is a limitation.
Conclusion:
No treatment is necessary for CCP because the skin lesions are asymptomatic and most patients experience at least partial regression.
