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Related Concept Videos

Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Related Experiment Video

Updated: Jun 11, 2026

Multimodality Diagnosis of Mesenteric Ischemia
05:07

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

[Kikuchi-Fujimoto disease].

L Astudillo1

  • 1Service de médecine interne, CHU Purpan, Toulouse cedex, France. Astudillo.l@chu-toulouse.fr

La Revue De Medecine Interne
|July 8, 2010
PubMed
Summary
This summary is machine-generated.

Kikuchi-Fujimoto disease is a rare necrotizing lymphadenitis primarily affecting young females, characterized by cervical lymphadenopathy and fever. Diagnosis relies on lymph node biopsy, with most cases resolving spontaneously.

Related Experiment Videos

Last Updated: Jun 11, 2026

Multimodality Diagnosis of Mesenteric Ischemia
05:07

Multimodality Diagnosis of Mesenteric Ischemia

Published on: July 21, 2023

Area of Science:

  • Pathology
  • Immunology

Context:

  • Kikuchi-Fujimoto disease (KFD) is a rare, benign, and self-limiting condition.
  • It is characterized by necrotizing lymphadenitis, predominantly affecting young women.

Purpose:

  • This abstract provides a concise overview of KFD, covering its clinical presentation, diagnostic criteria, and typical disease course.
  • It aims to inform healthcare professionals about this uncommon condition.

Summary:

  • KFD typically presents with localized, tender lymphadenopathy (especially cervical) and occasional fever in young patients.
  • Histopathological findings include necrotizing lymphadenitis with specific cellular infiltrates (histiocytes, plasmacytoid monocytes, apoptotic CD8+ T cells) and absence of neutrophils/eosinophils.
  • Laboratory findings may include leukopenia and elevated ESR. KFD can be associated with autoimmune diseases, pregnancy, and malignancies.

Impact:

  • Early recognition and diagnosis of KFD are crucial for appropriate patient management.
  • Understanding KFD's characteristics aids in differentiating it from other lymphoproliferative disorders.
  • The typically favorable prognosis means that interventions like corticosteroids are often unnecessary.