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Angiogenesis: Future of pharmacological modulation
Manisha Bisht1, D C Dhasmana, S S Bist
1Department of Pharmacology, Himalayan Institute of Medical Sciences, Dehradun, Uttarakhand, India.
Indian Journal of Pharmacology
|July 8, 2010
Summary
Angiogenesis, the formation of new blood vessels, is crucial for health and disease. Research into modulating this process holds potential for treating numerous conditions, from cancer to Alzheimer's disease.
Area of Science:
- Biomedical Science
- Molecular Biology
- Pathophysiology
Background:
- Angiogenesis is a vital biological process governed by a delicate equilibrium of pro- and antiangiogenic factors.
- Dysregulation of angiogenesis is implicated in numerous pathological conditions.
- Historically, its role was recognized mainly in cancer, arthritis, and psoriasis.
Purpose of the Study:
- To highlight the expanding understanding of angiogenesis's role in diverse diseases.
- To underscore the therapeutic potential of targeting angiogenesis for various disorders.
- To emphasize the transformative impact of angiogenesis research on 21st-century medicine.
Main Methods:
- Review of current scientific literature on angiogenesis.
- Analysis of the molecular mechanisms regulating blood vessel formation.
- Examination of the pathological roles of aberrant angiogenesis.
Main Results:
- Evidence indicates that excessive, insufficient, or abnormal angiogenesis contributes to many more diseases than previously understood.
- Angiogenesis research offers promising avenues for treating conditions like Alzheimer's disease and AIDS.
- The modulation of angiogenesis presents a significant frontier in medical treatment.
Conclusions:
- Aberrant angiogenesis is a common pathogenic factor across a wide spectrum of diseases.
- Targeting angiogenesis represents a major therapeutic strategy for numerous unmet medical needs.
- The impact of angiogenesis research may parallel the significance of antibiotics in the previous century.
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