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Updated: Jun 14, 2025
12:27
A Pipeline to Investigate the Structures and Signaling Pathways of Sphingosine 1-Phosphate Receptors
Published on: June 8, 2022
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Is Sphingosine Kinase 1 Associated with Hematological Malignancy? A Systematic Review and Meta-Analysis.
Sikha Morang1, Surabhi Thapliyal2, Vikas Upadhyay3
1Department of Pharmacology, All India Institute of Medical Sciences, Rishikesh, 249203, Uttarakhand, India.
Asian Pacific Journal of Cancer Prevention : APJCP
|August 29, 2024
Summary
Sphingosine kinase 1 (SphK1) expression is linked to hematological malignancies. This systematic review suggests SphK1 may be a therapeutic target for improving patient outcomes in these cancers.
Area of Science:
- Oncology
- Biochemistry
- Molecular Biology
Background:
- Sphingosine kinase 1 (SphK1) is a lipid enzyme implicated in cancer development.
- Its role in hematological malignancies requires further elucidation.
Approach:
- A systematic review and meta-analysis evaluated the association between SphK1 expression and hematological malignancy.
- Nine studies were included, with quality assessed using the Newcastle-Ottawa Scale.
- Pooled odds ratio was calculated to determine the strength of association.
Key Points:
- Meta-analysis revealed a significant positive association between SphK1 protein expression and hematological malignancies (OR = 52.37, P = 0.00001).
- No publication bias was detected, but the GRADE assessment indicated low certainty of evidence.
- Included studies were of moderate quality.
Conclusions:
- Findings support a link between SphK1 expression and hematological malignancies.
- SphK1 dysregulation may contribute to these cancers, positioning it as a potential therapeutic target.
- Further research is warranted to explore SphK1's mechanistic role and therapeutic potential.
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