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Updated: Jun 11, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Gold catalyzed diastereoselective cascade allylation/enyne cycloisomerization to construct densely functionalized
Zili Chen1, Yu-Xin Zhang, Ya-Hui Wang
1Department of Chemistry, Renmin University of China, Beijing 100872, China. zilichen@ruc.edu.cn
Abstract:
A new tandem allylation/enyne cycloisomerization reaction was developed to construct densely functionalized oxygen heterocycles with high diastereoselectivities from the intermolecular reaction of allylic acetates with propargylic alcohols via gold catalysis. Terminal and nonterminal propargylic alcohols take different reaction routes either to provide 3-oxa-bicyclo[4.1.0]hept-4-ene derivatives 5 or to give endocyclic rearrangement products 7 and alkoxycyclization adducts 8. Cyclopropane's stereochemistry was mainly determined by allylic substituents.
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