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Related Concept Videos

Fluid Mosaic Model01:19

Fluid Mosaic Model

Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich with the analogy of...
Fluid Mosaic Model01:34

Fluid Mosaic Model

The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.LipidsThe most...
Membrane Fluidity01:23

Membrane Fluidity

Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.Fatty acids tails of phospholipids can be either saturated or...
Membrane Fluidity01:26

Membrane Fluidity

Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is a relatively...
Phase Diagrams of Ternary Systems01:28

Phase Diagrams of Ternary Systems

Consider a ternary system, which is composed of three components: water (W), ethanoic acid (E), and trichloromethane (T). Here, Ethanoic acid (E) is fully miscible with both water (W) and trichloromethane (T), meaning it can mix entirely with either of them. However, water and trichloromethane have partial miscibility, meaning they can only mix to a certain extent, beyond which two separate phases will form.The phase diagram of a ternary system is represented as an equilateral triangle, where...
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with cytoskeletal...

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Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies
07:31

Realistic Membrane Modeling Using Complex Lipid Mixtures in Simulation Studies

Published on: September 1, 2023

Phase diagrams for multi-component membrane vesicles: a coarse-grained modeling study.

Chen Zheng1, Ping Liu, Ju Li

  • 1Department of Materials Science and Engineering, National University of Singapore, Singapore 119260.

Langmuir : the ACS Journal of Surfaces and Colloids
|July 9, 2010
PubMed
Summary
This summary is machine-generated.

This study introduces a multicomponent membrane model to simulate vesicle behavior. Budding off requires domains to exceed a critical size, influenced by spontaneous curvature and line tension, matching continuum model predictions.

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Area of Science:

  • Biophysics
  • Computational Biology
  • Materials Science

Background:

  • Membrane vesicles exhibit complex phase behaviors.
  • Understanding vesicle dynamics like budding is crucial for cellular processes.

Purpose of the Study:

  • To develop and utilize a coarse-grained model for multicomponent membrane vesicles.
  • To investigate phase segregation, domain coarsening, and budding phenomena.
  • To determine the critical conditions for membrane budding off.

Main Methods:

  • Development of a multicomponent membrane coarse-grained model incorporating spontaneous curvature and fluidity.
  • Performing computer simulations of vesicle dynamics.
  • Analyzing phase diagrams under varying composition, spontaneous curvature, and line tension.
  • Employing a continuum model to predict budding off criteria.

Main Results:

  • Observed various vesicle phases: sphere, biconcave, starfish, capsule, budding, and budding off.
  • Budding off was found to occur only when domain size surpassed a critical threshold.
  • The critical condition for budding off is significantly influenced by spontaneous curvature and line tension.

Conclusions:

  • The developed model accurately simulates multicomponent membrane vesicle behavior.
  • Simulation results for budding off conditions show good agreement with continuum model predictions.
  • Spontaneous curvature and line tension are key factors governing membrane vesicle budding.