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Five molecules we would take to a remote island.

Thomas U Mayer1, Andreas Marx

  • 1Konstanz Research School Chemical Biology, University of Konstanz, 78457 Konstanz, Germany. Thomas.u.mayer@uni-konstanz.de

Chemistry & Biology
|July 9, 2010
PubMed
Summary

Scientists select five impactful molecules—FK506, colchicine, imatinib, Quimi-Hib, and cidofovir—based on unique properties, scientific impact, and discovery stories, offering a personal perspective beyond common choices like water or aspirin.

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Area of Science:

  • Medicinal Chemistry
  • Molecular Biology
  • Pharmacology

Background:

  • The selection of essential molecules often focuses on survival needs, such as water and glucose.
  • Scientific curiosity prompts a deeper consideration of molecules based on their properties and discovery.
  • A personal, subjective list allows for highlighting diverse chemical and biological significance.

Purpose of the Study:

  • To present a curated list of five significant molecules that have impressed the authors.
  • To highlight the chemical properties, biological impact, and discovery narratives of selected compounds.
  • To offer a scientist's perspective on influential molecules beyond basic survival needs.

Main Methods:

  • A subjective selection process based on criteria such as molecular properties, scientific impact, and discovery context.
  • Identification and brief justification of five chosen molecules: FK506, colchicine, imatinib, Quimi-Hib, and cidofovir.
  • Personal reflection on the significance and noteworthy aspects of each selected compound.

Main Results:

  • The proposed list includes FK506 (immunosuppressant), colchicine (anti-gout, anti-mitotic), imatinib (targeted cancer therapy), Quimi-Hib (Haemophilus influenzae type b vaccine), and cidofovir (antiviral).
  • Each molecule is recognized for its distinct chemical structure, profound biological activity, or remarkable discovery story.
  • The selection emphasizes the breadth of molecular influence across medicine and scientific advancement.

Conclusions:

  • The chosen molecules represent significant achievements in chemistry and medicine, showcasing innovation and impact.
  • This subjective list serves as a starting point for appreciating the diverse roles molecules play in science and human health.
  • Further discussion and alternative selections by colleagues are encouraged to broaden the scope of influential compounds.