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Allergic Reactions: Anaphylaxis

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Related Experiment Video

Updated: Jun 11, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Perioperative anaphylaxis.

P M Mertes1, K Tajima, M A Regnier-Kimmoun

  • 1Service d'Anesthésie-Réanimation Chirurgicale, CHU de Nancy, Hôpital Central, 29 Avenue de Lattre de Tassigny, 54035 Nancy Cedex, France. pm.mertes@chu-nancy.fr

The Medical Clinics of North America
|July 9, 2010
PubMed
Summary
This summary is machine-generated.

Anesthesia-related anaphylaxis, a rare but serious immune reaction, affects 1 in 10,000 to 20,000 patients. Prompt diagnosis and treatment with epinephrine are crucial for managing this critical event.

Related Experiment Videos

Last Updated: Jun 11, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Area of Science:

  • Anesthesiology
  • Immunology
  • Clinical Medicine

Background:

  • Immune-mediated anaphylaxis during anesthesia is a rare but life-threatening adverse event.
  • The incidence is estimated between 1 in 10,000 and 1 in 20,000 anesthetic procedures.
  • Various agents, including neuromuscular blocking agents, latex, and antibiotics, are implicated.

Purpose of the Study:

  • To summarize the incidence, causes, diagnostic methods, and treatment of anaphylaxis during anesthesia.
  • To provide an overview of current understanding and management strategies for perioperative anaphylaxis.

Main Methods:

  • Review of literature on anaphylaxis during anesthesia.
  • Analysis of diagnostic approaches including tryptase measurements, skin tests, specific IgE, and basophil activation assays.
  • Summary of established treatment protocols involving volume expansion and epinephrine.

Main Results:

  • Neuromuscular blocking agents are the most common cause, followed by latex and antibiotics.
  • Diagnosis is confirmed through specific laboratory tests and assays.
  • Effective treatment requires immediate intervention with fluids and epinephrine.

Conclusions:

  • Anaphylaxis during anesthesia necessitates prompt recognition and management.
  • Accurate diagnosis relies on a combination of clinical suspicion and laboratory confirmation.
  • Timely administration of epinephrine is key to successful patient outcomes.