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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

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Updated: Jun 11, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Physical functioning in elderly persons with kidney disease.

Michelle C Odden1

  • 1Department of Medicine, University of California, San Francisco, 94143-1211, USA. michelle.odden@ucsf.edu

Advances in Chronic Kidney Disease
|July 9, 2010
PubMed
Summary
This summary is machine-generated.

Kidney disease significantly impairs physical function, especially in older adults. Interventions like anemia correction and exercise show promise but require more research in this vulnerable population.

Related Experiment Videos

Last Updated: Jun 11, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Area of Science:

  • Nephrology
  • Geriatrics
  • Physical Medicine

Background:

  • Poor physical functioning is common in dialysis patients.
  • Reduced kidney function is linked to worse physical function across various domains, even in mild cases.
  • Elderly individuals with kidney disease face heightened disability risks due to combined aging and kidney dysfunction effects.

Purpose of the Study:

  • To review current research on physical functioning in kidney disease patients.
  • To specifically focus on the impact of kidney disease on physical functioning in elderly populations.
  • To identify research gaps and needs for interventions in this demographic.

Main Methods:

  • Literature review of studies on physical functioning and kidney disease.
  • Synthesis of evidence regarding interventions for physical function.
  • Analysis of research focusing on older adults with kidney disease.

Main Results:

  • Anemia correction and physical activity can moderately improve physical function, primarily studied in younger, less comorbid populations.
  • Existing evidence for exercise interventions in older adults with kidney disease is encouraging but limited.
  • Older adults with kidney disease are underrepresented in clinical trials.

Conclusions:

  • Elderly individuals with kidney disease are at high risk for disability.
  • Further research is crucial to develop and test interventions preventing or mitigating poor physical functioning in this group.
  • Targeted interventions are needed to address the unique challenges faced by older adults with kidney disease.