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Updated: Jun 11, 2026
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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
Published on: February 8, 2020
[Multiple chromophobe renal cell carcinoma: a case report]
Naofumi Tsutsumi1, Takeshi Soda, Takashi Shimizu
1The Department of Urology, Kyoto University Graduate School of Medicine.
Hinyokika Kiyo. Acta Urologica Japonica
|July 9, 2010
Summary
This study details a rare case of chromophobe renal cell carcinoma. Despite initial combination therapy and subsequent immunotherapy, one tumor spontaneously resolved, highlighting the complex behavior of this kidney cancer.
Area of Science:
- Oncology
- Urology
Background:
- Bilateral multifocal chromophobe renal cell carcinoma (chRCC) is rare.
- Diagnosis was based on imaging findings of multiple renal tumors and lung nodules.
Observation:
- Initial combination therapy with interferon-alpha (IFN-alpha) and 5-flurouracil (5-FU) showed no response.
- IFN-alpha monotherapy led to partial regression of one tumor over six years.
- Immunotherapy discontinuation was considered due to potential benignity of lesions.
Findings:
- Spontaneous resolution of a right upper pole renal tumor occurred three years after discontinuing immunotherapy.
- Progressive disease in a contralateral renal tumor necessitated partial nephrectomy.
- Histological examination confirmed chromophobe renal cell carcinoma in excised tumors.
Implications:
- This case underscores the unpredictable clinical course of chromophobe renal cell carcinoma.
- It suggests a potential for spontaneous regression in some renal cell carcinoma subtypes.
- Further research into the mechanisms of tumor regression in chRCC is warranted.
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