Related Experiment Video
Updated: Jun 11, 2026
09:15
Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
Published on: May 7, 2019
ABO-incompatible kidney transplantation: current practice and the decade ahead
Russell J Crew1, Lloyd E Ratner
1Division of Nephrology, Department of Surgery, Columbia University, Presbyterian Hospital 4-124, 622 West 168th Street, New York, NY 10032, USA. rc395@columbia.edu
Current Opinion in Organ Transplantation
|July 9, 2010
Summary
ABO-incompatible kidney transplants offer comparable outcomes to standard transplants but face early rejection risks. New medications and improved antibody measurements aim to reduce these risks, expanding options for patients needing kidney transplants.
Area of Science:
- Nephrology
- Transplantation Immunology
- Pharmacology
Background:
- Kidney transplant waiting lists are growing, necessitating innovative solutions.
- ABO-incompatible transplantation is a key strategy to address donor organ shortages.
Purpose of the Study:
- To review current outcomes and emerging therapies for ABO-incompatible kidney transplantation.
- To explore how advancements can broaden the application of these transplants.
Main Methods:
- Review of current literature on ABO-incompatible kidney transplant outcomes.
- Analysis of emerging pharmacologic interventions and diagnostic improvements.
- Examination of preclinical and clinical studies on novel rejection-prevention strategies.
Main Results:
- ABO-incompatible kidney transplant outcomes are comparable to standard transplants.
- Significant early antibody-mediated rejection remains a primary challenge.
- Rituximab has largely replaced splenectomy, with similar efficacy and reduced invasiveness.
- Complement inhibitors show promise in preclinical and ongoing human studies.
- Ex vivo antigen removal and accommodation strategies are under investigation.
Conclusions:
- Reducing early rejection is crucial for widespread adoption of ABO-incompatible kidney transplants.
- Pharmacologic advancements and improved diagnostics will enhance patient safety.
- Broader implementation of ABO-incompatible transplantation, alongside paired exchange, can help alleviate organ shortages.
Related Concept Videos
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:16Kidney Transplant III: Nursing Management
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
01:24Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...