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Adherence compounds in embryo transfer media for assisted reproductive technologies
Stephan Bontekoe1, Debbie Blake, Maas Jan Heineman
1University of Amsterdam, Amsterdam, Netherlands.
The Cochrane Database of Systematic Reviews
|July 9, 2010
Summary
Adherence compounds in assisted reproductive technologies (ART) show improved clinical pregnancy rates but do not affect live birth rates. Further research is needed for single embryo transfer applications.
Area of Science:
- Reproductive Medicine
- Infertility Treatment
- Assisted Reproductive Technologies
Background:
- Adherence compounds like hyaluronic acid and fibrin sealant are used in assisted reproductive technologies (ART) to enhance embryo implantation.
- These compounds are added to embryo transfer media with the aim of increasing clinical pregnancy and live birth rates.
Purpose of the Study:
- To evaluate the impact of adherence compounds in embryo transfer media on live birth rates in ART.
- Comparison between media with and without adherence compounds.
Main Methods:
- Systematic review and meta-analysis of randomized controlled trials.
- Searched multiple databases (e.g., CENTRAL, MEDLINE, EMBASE) up to May 2009.
- Included trials comparing adherence compounds (hyaluronic acid, fibrin sealant) with standard media.
Main Results:
- Sixteen studies with 3698 participants were analyzed.
- No significant effect of fibrin sealant on live birth rate.
- Hyaluronic acid showed no effect on live birth rate but increased clinical pregnancy (OR 1.41) and multiple pregnancy rates (OR 1.86).
Conclusions:
- Adherence compounds improve clinical pregnancy rates in ART but do not influence live birth rates.
- Increased multiple pregnancy rates may be linked to combined use of compounds and multiple embryo transfer.
- Further studies are recommended for adherence compounds with single embryo transfer.
