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Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

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Related Experiment Video

Updated: Jun 11, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
09:34

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis

Published on: August 16, 2021

How research can help control tuberculosis.

R E Chaisson1, M Harrington

  • 1Johns Hopkins University Center for Tuberculosis Research, Baltimore, Maryland, USA.

World Hospitals and Health Services : the Official Journal of the International Hospital Federation
|July 10, 2010
PubMed
Summary
This summary is machine-generated.

Tuberculosis (TB) research has historically yielded valuable tools but stalled, leading to control failures. Renewed investment in basic and applied research is crucial for developing new diagnostics, drugs, vaccines, and effective population-level strategies to combat this persistent disease.

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A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
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Published on: March 24, 2017

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Last Updated: Jun 11, 2026

An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
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Published on: August 16, 2021

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
10:29

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis

Published on: March 24, 2017

Area of Science:

  • Biomedical Science
  • Infectious Disease Research
  • Public Health

Background:

  • Tuberculosis (TB) research historically produced key diagnostic, therapeutic, and preventive tools.
  • Research significantly declined after the 1970s/80s chemotherapy advancements, despite TB remaining a major global health threat.
  • Current TB control is hampered by tool limitations and inadequate implementation, exacerbated by HIV-TB co-infection and multidrug-resistant TB.

Purpose of the Study:

  • To highlight the historical trajectory and current state of tuberculosis research.
  • To identify critical research needs for effective global TB control in the 21st century.
  • To underscore the necessity for increased funding and a robust research agenda.

Main Methods:

  • Literature review and historical analysis of TB research trends.
  • Epidemiological assessment of current TB challenges, including drug resistance and HIV co-infection.
  • Analysis of global funding for TB research in relation to stated control goals.

Main Results:

  • Despite past successes, TB research has stagnated, leading to control faltering.
  • Existing TB diagnostic, therapeutic, and preventive tools have significant shortcomings.
  • Emerging challenges like HIV-TB and multidrug-resistant TB necessitate novel approaches.

Conclusions:

  • A comprehensive research agenda is essential, encompassing basic science for pathogenesis understanding and applied science for improved biomedical tools.
  • Effective population-level application strategies for both existing and new tools require urgent research.
  • Substantial increases in global TB research funding are imperative to meet ambitious TB control targets.