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Bioactive isoflavones from Dalbergia vacciniifolia (Fabaceae)
Ester Innocent1, Joseph J Magadula, Charles Kihampa
1Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania. einnocent@muhas.ac.tz
Abstract:
Three new 5-dehydroxy isoflavone compounds, 6,2'-dimethoxy-7,4'-dihydroxyisoflavone (1), 6,2',4'-trimethoxy-7-hydroxyisoflavone (2), and 6,2',4',5'-tetramethoxy-7-O-[beta-D-apiofuranosyl-(1 --> 6)-beta-D-glucopyranoside] isoflavone (3), along with a known isoflavone, 6,2',4',5'-tetramethoxy-7-hydroxyisoflavone (4), were isolated from the ethanolic extract of Dalbergia vacciniifolia Vatke. Their structures were established by spectroscopic techniques including one- and two-dimension NMR. Compound 1 showed mild cytotoxic activity against brine shrimp larvae with a LC50 value of 266 microg/mL.
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