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Related Concept Videos

Male Sexual Response: Erection & Ejaculation01:17

Male Sexual Response: Erection & Ejaculation

Sexual stimulation can take various forms, such as physical touch and visual or auditory cues. When this happens, the parasympathetic reflex in the sacral portion of the spinal cord is activated. This reflex stimulates the release of nitric oxide (NO), which then dilates the arterioles in the penis, increasing blood flow to the erectile tissues - the corpora cavernosa and corpus spongiosum.
The blood filling the erectile tissues compresses the veins, which helps to prevent blood from leaving...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
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Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

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Related Experiment Video

Updated: Jun 11, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Dapoxetine: in premature ejaculation.

Sheridan M Hoy1, Lesley J Scott

  • 1Adis, a Wolters Kluwer Business, Auckland, New Zealand. demail@adis.co.nz

Drugs
|July 10, 2010
PubMed
Summary

Dapoxetine, a selective serotonin reuptake inhibitor, is an effective oral treatment for premature ejaculation in men aged 18-64. Studies show it significantly improves intravaginal ejaculatory latency time and sexual satisfaction compared to placebo.

Area of Science:

  • Pharmacology
  • Urology
  • Men's Health

Background:

  • Premature ejaculation (PE) is a common male sexual dysfunction.
  • Selective serotonin reuptuptake inhibitors (SSRIs) have shown potential in managing PE.

Purpose of the Study:

  • To evaluate the efficacy and safety of dapoxetine for treating premature ejaculation.
  • To assess the long-term effects of dapoxetine on sexual function and patient-reported outcomes.

Main Methods:

  • Four randomized, double-blind, placebo-controlled studies.
  • Dapoxetine 30 or 60 mg administered as needed.
  • Primary endpoint: intravaginal ejaculatory latency time (IELT).
  • Secondary endpoints: Premature Ejaculation Profile (PEP) and Global Impression ratings.

Related Experiment Videos

Last Updated: Jun 11, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Main Results:

  • Dapoxetine significantly improved IELT compared to placebo (p < 0.001).
  • Significant improvements were observed in secondary endpoints, including control over ejaculation and sexual satisfaction.
  • Benefits were sustained over a 9-month extension phase.

Conclusions:

  • Dapoxetine is an effective oral treatment for premature ejaculation in men aged 18-64.
  • The therapy is generally well-tolerated with a safety profile consistent across studies.
  • Dapoxetine offers sustained improvements in sexual function and satisfaction for men with PE.