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METAL: fast and efficient meta-analysis of genomewide association scans

Cristen J Willer1, Yun Li, Gonçalo R Abecasis

  • 1Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA.

Bioinformatics (Oxford, England)
|July 10, 2010
PubMed
Abstract

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...