Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Responses to Heat and Cold Stress02:45

Responses to Heat and Cold Stress

Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
Psychological Responses to Stress01:20

Psychological Responses to Stress

Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
Pharmacodynamic Responses: Different Types01:03

Pharmacodynamic Responses: Different Types

Pharmacodynamics is the scientific study of a drug's biochemical or physiological influence on the body. It categorizes responses into continuous, discrete (or categorical), and time-to-event outcomes. Continuous responses yield numerical values within a certain range, such as blood pressure readings and blood glucose levels, gauging the efficacy of antihypertensive and antidiabetic drugs. Discrete responses can be binary, indicating whether a drug has an effect or not, or ordinal, exemplifying...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial.

JAMA·2026
Same author

Postresuscitation Cerebral Vasospasm and Capillary Failure After Experimental Asphyxial Cardiac Arrest.

Journal of the American Heart Association·2026
Same author

Association of Race and Ethnicity With Computed Tomography Head Utilization in Children Presenting to the Emergency Department With an Unprovoked Seizure.

Pediatric neurology·2026
Same author

Characteristics and Short-Term Outcomes of Patients With Acute Pulmonary Embolism Requiring Intubation.

Academic emergency medicine : official journal of the Society for Academic Emergency Medicine·2026
Same author

Implementation of High-Flow Nasal Cannula and Noninvasive Ventilation During Pediatric Interfacility Transport: Effect on Intubation Rates.

Air medical journal·2026
Same author

Volume therapy for cardiac arrest: a systematic review and meta-analysis.

Resuscitation plus·2026

Related Experiment Video

Updated: Jun 11, 2026

An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap
09:16

An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap

Published on: January 16, 2014

The multidimensional physiological responses to postconditioning.

Jakob Vinten-Johansen1, Asger Granfeldt, James Mykytenko

  • 1Department of Surgery (Cardiothoracic), Carlyle Fraser Heart Center, Emory University, 550 Peachtree Street NE, Atlanta, GA 30308-2225, USA. jvinten@emory.edu

Antioxidants & Redox Signaling
|July 13, 2010
PubMed
Summary
This summary is machine-generated.

Postconditioning protects heart tissue from reperfusion injury by activating complex physiological and molecular mechanisms. This integrated approach offers a promising therapeutic strategy for reducing myocardial damage and improving outcomes.

More Related Videos

Non-invasive Assessments of Subjective and Objective Recovery Characteristics Following an Exhaustive Jump Protocol
08:21

Non-invasive Assessments of Subjective and Objective Recovery Characteristics Following an Exhaustive Jump Protocol

Published on: June 8, 2017

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Related Experiment Videos

Last Updated: Jun 11, 2026

An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap
09:16

An Alternative to the Traditional Cold Pressor Test: The Cold Pressor Arm Wrap

Published on: January 16, 2014

Non-invasive Assessments of Subjective and Objective Recovery Characteristics Following an Exhaustive Jump Protocol
08:21

Non-invasive Assessments of Subjective and Objective Recovery Characteristics Following an Exhaustive Jump Protocol

Published on: June 8, 2017

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Area of Science:

  • Cardiovascular Research
  • Ischemia-Reperfusion Injury
  • Cardioprotection

Background:

  • Reperfusion is crucial for reducing infarct size but paradoxically causes postischemic injury.
  • Coronary vascular endothelium and cardiomyocytes are susceptible to reperfusion-induced damage.
  • Current reperfusion therapies have limitations in achieving optimal tissue salvage.

Purpose of the Study:

  • To explore the protective effects of postconditioning against reperfusion injury.
  • To elucidate the complex physiological and molecular mechanisms underlying postconditioning's efficacy.
  • To highlight the integrated, multi-target approach of postconditioning.

Main Methods:

  • Investigated the impact of postconditioning on various cardiac tissue types (cardiomyocytes, endothelium).
  • Examined the protection offered against pathological processes like necrosis, apoptosis, and microvascular injury.
  • Analyzed the interplay of physiological (pH, autacoids, channels) and molecular (kinase activation) mechanisms.

Main Results:

  • Postconditioning demonstrates salubrious effects across different cardiac tissues.
  • It protects against necrosis, apoptosis, contractile dysfunction, arrhythmias, and no-reflow.
  • The mechanisms involve integrated physiological and molecular pathways, not isolated responses.

Conclusions:

  • Postconditioning offers a multi-faceted therapeutic approach to mitigate reperfusion injury.
  • Its integrated response contrasts with less effective monotherapy strategies.
  • This approach shows promise across species and in human clinical trials for reducing reperfusion damage.