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Appendicitis

Appendicitis

Appendicitis is an acute inflammatory condition of the vermiform appendix, most commonly caused by obstruction of its lumen. The appendix is a narrow, blind-ended pouch that extends from the cecum, making it particularly prone to obstruction. Causes include fecaliths, lymphoid hyperplasia (often after viral infections), parasites, tumors, or foreign bodies. This obstruction initiates a cascade of pathological changes.Luminal Obstruction and Early InflammationAfter obstruction, normal mucosal...

Appendicitis-I: Introduction

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...

Appendicitis-II: Diagnostic Studies and Management

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...

Inflammatory Bowel Disease III: Crohn's Disease

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Inflammatory Bowel Disease II: Crohn's Disease

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
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Inflammatory Bowel Disease V: Surgical Management

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Related Experiment Video

Updated: Jun 11, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

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Published on: August 24, 2019

[Acute appendicitis with goblet cell carcinoid].

Niels G Koopmans¹, Herry W S Kwee, Jeroen Heemskerk

¹Universteit Maastricht, Maastricht, the Netherlands.

Nederlands Tijdschrift Voor Geneeskunde

|July 13, 2010

Summary

A rare goblet cell carcinoid tumor was unexpectedly discovered in a patient initially diagnosed with acute appendicitis. Histological examination is crucial for diagnosing such rare appendiceal tumors and guiding appropriate treatment.

Area of Science:

Gastroenterology
Surgical Pathology
Oncology

Background:

Appendicitis is a common surgical emergency.
Goblet cell carcinoid tumors are rare appendiceal neoplasms.
Accurate diagnosis is essential for appropriate management.

Observation:

A 43-year-old male presented with acute right lower quadrant abdominal pain.
Initial diagnosis was acute appendicitis, leading to appendicectomy.
Histological examination revealed a small goblet cell carcinoid (histological group C) with acute inflammation.

Findings:

The goblet cell carcinoid tumor was incidentally discovered during histological examination post-appendicectomy.
Tumor cells were identified within a lymph duct at the appendix base, indicating potential for spread.

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This highlights the importance of thorough histological analysis even in common presentations.

Implications:

Histological examination is critical for identifying rare appendiceal tumors that may be missed otherwise.
Treatment strategies for appendiceal carcinoids should be based on histological classification and staging.
Early and accurate diagnosis can significantly impact patient outcomes for rare appendiceal neoplasms.