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Updated: Jun 11, 2026
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Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses
Published on: April 4, 2019
Bovine respiratory syncytial virus
1Veterinary Diagnostic Center, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68506-0907, USA. bbrodersen1@unl.edu
Summary
Bovine respiratory syncytial virus (BRSV) causes significant respiratory illness in cattle. Vaccines using inactivated virus have unfortunately worsened disease in both cattle and human infants, highlighting risks.
Area of Science:
- Veterinary Virology
- Immunology
- Animal Health
Background:
- Bovine respiratory syncytial virus (BRSV) is a primary pathogen in the bovine respiratory disease (BRD) complex.
- BRSV infection affects the upper and lower respiratory tracts, leading to viral shedding in nasal secretions.
- Its genetic similarity to human respiratory syncytial virus (HRSV) facilitates comparative disease mechanism studies.
Purpose of the Study:
- To provide a comprehensive overview of Bovine respiratory syncytial virus (BRSV).
- To discuss epidemiology, pathogenesis, diagnostics, immunity, and vaccination strategies for BRSV.
- To highlight the risks associated with formalin-inactivated vaccines based on historical data.
Main Methods:
- Review of existing literature on BRSV.
- Analysis of BRSV's relationship with HRSV for disease mechanism insights.
- Examination of vaccine trial outcomes, particularly those involving inactivated virus.
Main Results:
- Formalin-inactivated vaccines led to enhanced disease severity in cattle challenged with BRSV.
- Similar vaccine-induced enhanced disease was observed in infants exposed to HRSV.
- BRSV pathogenesis, diagnostic methods, and immune responses are detailed.
Conclusions:
- The study underscores the significant impact of BRSV on cattle health and the economy.
- Evidence suggests formalin-inactivated vaccines pose a risk of disease enhancement.
- Further research into effective and safe BRSV vaccination is crucial.
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