Outcomes of treatment of childhood achalasia

Constance W Lee1, David W Kays, Mike K Chen

  • 1Division of Pediatric Surgery, University of Florida College of Medicine, PO Box 100119, Gainesville, FL 32610, USA.

Insights

Heller myotomy is more effective for treating pediatric achalasia than esophageal dilation, leading to fewer recurrences and less need for further procedures. This surgical approach offers more durable outcomes for children and adolescents with achalasia.

Area of Science:

  • Pediatric Gastroenterology
  • Surgical Innovation
  • Esophageal Motility Disorders

Background:

  • Achalasia management in pediatric patients lacks a clear consensus.
  • This study examines endoscopic and surgical treatments for achalasia in children and adolescents.

Purpose of the Study:

  • To review a single institution's experience with endoscopic and surgical interventions for pediatric achalasia.
  • To compare the long-term outcomes of different treatment modalities.

Main Methods:

  • Retrospective review of medical records for children diagnosed with achalasia between 1978 and 2008.
  • Analysis of patient demographics, interventions (esophageal dilation vs. Heller myotomy), and procedural outcomes.
  • Evaluation of symptom recurrence and need for subsequent interventions.

Main Results:

  • Thirty-four pediatric patients with achalasia were analyzed; 18 underwent esophageal dilation (ED) and 16 underwent Heller myotomy (HM).
  • Symptom recurrence was significantly higher in the ED group (15/15) compared to the HM group (8/15; P < .01).
  • Additional interventions were required in 93% of ED cases versus 40% of HM cases (P < .01).

Conclusions:

  • Heller myotomy demonstrates superior long-term efficacy in pediatric achalasia management.
  • The surgical approach is associated with lower symptom recurrence and reduced need for re-intervention.
  • Heller myotomy is recommended as the preferred procedure for achalasia in children and adolescents.
Abstract

Related Concept Videos

Esophageal Achalasia01:27

Esophageal Achalasia

Esophageal achalasia is a chronic neurogenic disorder characterized by impaired relaxation of the lower esophageal sphincter (LES) and absent or ineffective peristalsis in the distal esophagus. This leads to a functional obstruction without a physical blockage, despite significant disruption of esophageal motility.EtiologyAchalasia is caused by degeneration of the myenteric (Auerbach's) plexus, specifically the loss of inhibitory ganglion cells that produce vasoactive intestinal peptide (VIP)...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Direct-Acting Cholinergic Agonists: Therapeutic Uses01:11

Direct-Acting Cholinergic Agonists: Therapeutic Uses

Direct-acting cholinergic agonists have many therapeutic uses in various medical fields. Choline esters, including acetylcholine, have limited clinical utility due to their non-selectivity and short duration of action. Still, acetylcholine and carbachol are applied topically during ophthalmologic surgery to induce miosis. Pilocarpine, a muscarinic and ganglionic stimulator, effectively treats open-angle glaucoma and alleviates xerostomia and dry mouth caused by radiotherapy or Sjögren syndrome.