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Updated: Jun 11, 2026
05:17
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Structure-based design and synthesis of pyrrole derivatives as MEK inhibitors
Michael B Wallace1, Mark E Adams, Toufike Kanouni
1Takeda San Diego, 10410 Science Center Drive, San Diego, CA 92121, United States. michael.wallace@takedasd.com
Bioorganic & Medicinal Chemistry Letters
|July 13, 2010
Abstract:
A novel series of pyrrole inhibitors of MEK kinase has been developed using structure-based drug design. Optimization of the series led to the identification of potent inhibitors with good pharmaceutical properties.
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