Related Experiment Video
Updated: Jun 11, 2026
11:30
A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
Relationship between renal stone formation, mitral annular calcification and bone resorption markers
Ahmet Celik1, Vedat Davutoglu, Kemal Sarica
1Department of Cardiology, Gaziantep University, School of Medicine, Gaziantep, Turkey.
Annals of Saudi Medicine
|July 13, 2010
Summary
Renal stone formation (RSF) is linked to mitral annular calcification (MAC), suggesting a connection to bone resorption. Further studies are needed to clarify this association between RSF, MAC, and bone loss.
Area of Science:
- Cardiovascular Health
- Nephrology
- Bone Metabolism
Background:
- Mitral annular calcification (MAC) is linked to osteoporosis.
- Reduced bone mineral density (BMD) is observed in patients with renal stone formation (RSF).
Purpose of the Study:
- To investigate the association between RSF and MAC.
- To determine if bone resorption markers mediate the RSF-MAC relationship.
Main Methods:
- Fifty-nine RSF patients and 40 controls were screened for MAC and BMD.
- Serum and urine electrolytes, parathyroid hormone, alkaline phosphatase, and urine pyridoline were measured.
Main Results:
- MAC was more prevalent in RSF patients (18%) than controls (2.5%).
- RSF patients showed altered electrolyte and alkaline phosphatase levels.
- MAC presence correlated with higher urine pyridoline and more negative T-scores (osteopenia).
Conclusions:
- A high incidence of MAC was observed in RSF patients.
- MAC in RSF patients is associated with markers of bone resorption.
- The complex interplay between RSF, MAC, and bone loss requires further investigation.
Related Concept Videos
01:31Osteoclasts in Bone Remodeling
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
01:28Urinary Tract Calculi I: Introduction
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
01:30Urinary Tract Calculi III: Medical Management
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
01:40Bone Remodeling
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
01:27Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...