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Updated: Jun 11, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
Effect of continuous ingestion of acetic Acid bacteria on memory retention and the synaptic function in aged rats
Hiroyuki Fukami1, Satoru Kobayashi, Hideki Tachimoto
1Central Research Institute, Mizkan Group Corporation, Handa, Aichi. h-fukami@mizkan.co.jp
Abstract:
We administered Acetobacter malorum NCI1683 (S24), containing a high concentration of dihydroceramide (7.2 mg/g of dry cell weight), consecutively to aged rats (male Crlj:Wistar rats, 22 months old). The ingestion of Acetobacter malorum for 89 d significantly extended the memory retention in passive avoidance tests, increased the release of acetylcholine with depolarization of brain synaptosomes and decreased the causative agents of neurodegenerative diseases in the cerebral cortices.

