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Growth hormone, exercise, and athletic performance: a continued evolution of complexity.
William J Kraemer1, Courtenay Dunn-Lewis, Brett A Comstock
1Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA. William.Kraemer@uconn.edu
Current Sports Medicine Reports
|July 13, 2010
Summary
Growth hormone (hGH) has diverse effects, but its various forms and functions remain complex. Further research is needed to understand all hGH isoforms and their roles in physiology and supplementation.
Area of Science:
- Endocrinology
- Molecular Biology
- Physiology
Background:
- Human growth hormone (hGH) exhibits pleiotropic effects across numerous tissues.
- The complexity of hGH, including various isoforms and molecular functions, complicates current understanding.
- Most research focuses on the 22 kD monomer, neglecting other circulating forms.
Purpose of the Study:
- To investigate the influence and biological activity of non-22 kD hGH isoforms.
- To clarify the role of hGH and its supplementation throughout the lifespan.
- To highlight the need for advanced analytical techniques in studying pituitary function.
Main Methods:
- Review of existing literature on hGH isoforms and their functions.
- Analysis of studies examining hGH supplementation effects.
- Discussion of advancements in hGH testing and detection.
Main Results:
- The biological activity of various hGH isoforms is not fully understood.
- Results regarding hGH's role and supplementation efficacy are often equivocal.
- The first positive test for hGH use has been recently reported.
Conclusions:
- A comprehensive understanding of hGH requires studying all isoforms, not just the 22 kD monomer.
- Further research is essential to resolve conflicting findings on hGH's physiological roles and supplementation.
- Wider adoption of advanced analytical methods is crucial for a complete understanding of pituitary function.
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