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Related Experiment Video

Updated: Jun 11, 2026

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

Aptamer applications for targeted cancer therapy.

Andrew S Barbas¹, Jing Mi, Bryan M Clary

¹Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

Future Oncology (London, England)

|July 14, 2010

Summary

Aptamers, which are DNA or RNA molecules, show high specificity for cancer targets. These aptamers are being developed for targeted cancer therapy and drug delivery systems.

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Area of Science:

Biochemistry
Molecular Biology
Oncology

Background:

Aptamers are single-stranded DNA or RNA oligonucleotides with high affinity for target molecules.
Their specific 3D structures enable precise binding to targets.
Aptamers are increasingly recognized for their potential in targeted cancer therapy.

Purpose of the Study:

To review recent advancements in aptamer applications for cancer therapy.
To highlight novel strategies utilizing aptamers targeting cell surface proteins.
To explore aptamers as delivery agents for therapeutic payloads.

Main Methods:

Literature review of recent studies on aptamer-based cancer therapy.
Analysis of aptamer development against various cancer targets.
Examination of aptamer incorporation into novel therapeutic constructs.

Main Results:

Aptamers have been successfully developed against diverse cancer targets, including cell surface proteins and extracellular ligands.
Novel constructs incorporating aptamers with siRNAs, chemotherapeutics, toxins, and nanoparticles have been created.
Aptamers function effectively as delivery agents for therapeutic cargo in these constructs.

Conclusions:

Aptamers offer high specificity and affinity, making them promising agents for targeted cancer treatment.
Recent developments focus on novel applications, especially targeting cell surface receptors.
Aptamer-based strategies are advancing cancer therapy through targeted delivery and novel therapeutic combinations.