Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Planar cell polarity protein Vangl2 interacts with M-cadherin and stabilizes its cell surface expression in mouse C2C12 myoblasts.

Frontiers in cell and developmental biology·2026

Same author

Statins attenuate PD-L1 sorting to small extracellular vesicles dependent on ubiquitin-like 3 modification.

Scientific reports·2025

Same author

Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.

Cancer research communications·2024

Same author

Spatiotemporal modulation of growth factors directs the generation of multilineage mouse embryonic stem cell-derived mammary organoids.

Developmental cell·2023

Same author

Reverse Transfection of Functional RNA Rings into Cancer Cells Followed by in Vitro Irradiation.

Methods in molecular biology (Clifton, N.J.)·2023

Same author

Cancer stem cells as the source of tumor associated myoepithelial cells in the tumor microenvironment developing ductal carcinoma in situ.

Biomaterials·2023

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector

Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector

Published on: February 2, 2021

Cripto-1: an embryonic gene that promotes tumorigenesis.

Nadia Pereira de Castro¹, Maria Cristina Rangel, Tadahiro Nagaoka

¹Mammary Biology & Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr., Bethesda, MD 20892, USA.

Future Oncology (London, England)

|July 14, 2010

Summary

Cripto-1, a key embryonic gene, is re-expressed in tumors, driving cancer growth and stem-like traits. Inhibiting Cripto-1 may offer a novel cancer therapy targeting both cancer and stem cells.

More Related Videos

A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster

A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster

Published on: September 11, 2013

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles

Published on: February 1, 2020

Related Experiment Videos

Last Updated: Jun 11, 2026

Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector

Tumor Allotransplantation in Drosophila melanogaster with a Programmable Auto-Nanoliter Injector

Published on: February 2, 2021

A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster

A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster

Published on: September 11, 2013

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles

LINE-1 Methylation Analysis in Mesenchymal Stem Cells Treated with Osteosarcoma-Derived Extracellular Vesicles

Published on: February 1, 2020

Area of Science:

* Developmental Biology
* Oncology
* Molecular Biology

Background:

* Cell fate regulation in embryonic development and cancer involves shared pathways.
* Cripto-1 (Epidermal Growth Factor-Cripto-1/FRL1/Cryptic family) is crucial for embryogenesis and carcinogenesis.
* Cripto-1 and Nodal are key regulators of embryonic development and markers of undifferentiated stem cells.

Purpose of the Study:

* To investigate the role of Cripto-1 in cancer development and progression.
* To explore the potential of Cripto-1 as a therapeutic target in oncology.
* To assess the feasibility of inhibiting Cripto-1 for cancer treatment.

Main Methods:

* Review of existing studies on Cripto-1 function in development and cancer.
* Analysis of Cripto-1 expression patterns in normal adult tissues versus tumors.
* Discussion of potential therapeutic strategies targeting Cripto-1, including blocking antibodies and antisense vectors.

Main Results:

* Cripto-1 expression is minimal in normal adult tissues but significantly upregulated in various human tumors.
* Cripto-1 influences cancer cell proliferation, migration, epithelial-to-mesenchymal transition, and tumor angiogenesis.
* Cripto-1 is associated with stem-like characteristics in tumor cell subpopulations.

Conclusions:

* Cripto-1 plays a significant role in oncogenesis and is linked to tumor-promoting activities.
* Targeting Cripto-1 offers a promising therapeutic strategy for various cancers.
* Inhibition of Cripto-1 may effectively treat both differentiated cancer cells and cancer stem cells.