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Published on: April 14, 2011
Kawasaki disease associated with parainfluenza type 3 virus infection
Ana Moreira1, Inês Leite, Armando Baptista
1Dermatology Department Centro Hospitalar de Vila Nova de Gaia/Espinho, Rua Conceição Fernandes, Vila Nova de Gaia, Portugal. anadmoreira@gmail.com
Insights
Kawasaki disease (KD), a childhood vasculitis, may be linked to parainfluenza type 3 infections. This case report suggests a potential infectious trigger for KD, impacting pediatric cardiology.
Area of Science:
- Pediatric Rheumatology
- Infectious Diseases
- Cardiology
Background:
- Kawasaki disease (KD) is a critical pediatric vasculitis affecting coronary arteries, leading to acquired heart disease.
- The exact cause of KD remains unknown, but an infectious etiology is suspected.
- Parainfluenza viruses, particularly type 3, are known causes of respiratory illness in children.
Observation:
- This report details a case of typical Kawasaki disease occurring concurrently with a parainfluenza type 3 infection.
- The patient presented with classic symptoms of KD during the active viral infection.
Findings:
- The co-occurrence suggests a potential association between parainfluenza type 3 and the development of Kawasaki disease.
- This finding warrants further investigation into viral triggers for KD.
Implications:
- Identifying infectious agents like parainfluenza virus could lead to better understanding and management of Kawasaki disease.
- This research may open new avenues for diagnosing and potentially preventing KD in children.
- Understanding the link between viral infections and vasculitis is crucial for pediatric cardiovascular health.
Abstract:
Kawasaki disease (KD) is an acute, febrile and multisystem vasculitis of early childhood with a striking predilection for the coronary arteries. In developed countries, the incidence of KD has replaced acute rheumatic fever as the leading cause of acquired heart disease in children. The etiologic agent of KD remains unknown, although clinical and epidemiologic features strongly indicate an infectious cause. Parainfluenza viruses are the major cause of laryngotracheobronchitis (croup), but they also commonly cause upper respiratory tract infection, pneumonia, or bronchiolitis. Types 1 and 2 viruses are the most common pathogens associated with croup, and type 3 viruses are associated with bronchiolitis and pneumonia in infants and young children. Rarely, mumps, aseptic meningitis, and encephalitis have been associated with type 3 infections. We report a patient with typical KD during parainfluenza type 3 infection.
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