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Protein Families

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key locations, protein...

Protein Families

Protein Families

Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key locations, protein...

Protein and Protein Structure

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

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Related Experiment Video

Updated: Jun 11, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

PROFESS: a PROtein function, evolution, structure and sequence database.

Thomas Triplet¹, Matthew D Shortridge, Mark A Griep

¹Department of Computer Science and Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0115, USA.

Database : the Journal of Biological Databases and Curation

|July 14, 2010

Summary

This summary is machine-generated.

The PROFESS database aids protein analysis by integrating function, evolution, structure, and sequence data. It enables novel data relationship discovery for biological research and therapeutic target identification.

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Last Updated: Jun 11, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Area of Science:

Bioinformatics
Computational Biology
Molecular Biology

Background:

The rapid growth of biological databases and internet accessibility is revolutionizing biological sciences.
Over 1100 molecular biology databases are currently available online.
Analyzing novel proteins from whole-genome sequencing requires advanced tools for functional, structural, and evolutionary insights.

Purpose of the Study:

To introduce the PROFESS (PROtein Function, Evolution, Structure and Sequence) database.
To provide a versatile and expandable platform for protein analysis.
To develop an intuitive query system for discovering novel data relationships.

Main Methods:

The PROFESS database integrates protein function, evolution, structure, and sequence data.
An intuitive query system with diverse similarity functions allows for the generation of new data relationships.
Analysis of structural drift in homologous proteins and protein-protein interaction networks.

Main Results:

Demonstrated utility of PROFESS in analyzing structural drift of homologous proteins.
Identified potential therapeutic targets for pancreatic cancer through protein-protein interaction network analysis.
The database design supports versatile and expandable data analysis.

Conclusions:

The PROFESS database offers a powerful tool for comprehensive protein analysis.
Its flexible query system facilitates the discovery of previously unknown biological insights.
PROFESS aids in identifying potential therapeutic targets and understanding protein evolution.