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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
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IL-10 and TNFalpha genotypes in SLE.

Patricia López1, Carmen Gutiérrez, Ana Suárez

  • 1Department of Functional Biology, Immunology Area, University of Oviedo, Oviedo, Asturias, Spain.

Journal of Biomedicine & Biotechnology
|July 14, 2010
PubMed
Summary

Genetic variations in interleukin 10 (IL-10) and tumor necrosis factor alpha (TNFalpha) influence Systemic Lupus Erythematosus (SLE) development and clinical outcomes. These cytokine gene polymorphisms play a significant role in SLE pathogenesis.

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