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Exploring ChatGPT's clinical role in prosthodontics: a systematic review
Victor Díaz-Flores García1, Susana David Fernández2, Giuseppe D'Albis3
1Department of Preclinical Dentistry I, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Spain.
Minerva Dental and Oral Science
|May 18, 2026
Summary
Artificial intelligence (AI) tools like ChatGPT show promise in prosthodontics for diagnosis and treatment planning. However, direct clinical use requires caution and further validation due to current limitations.
Area of Science:
- Dental Technology
- Artificial Intelligence in Medicine
- Prosthodontics
Background:
- Artificial intelligence (AI) integration offers new diagnostic and treatment planning avenues in clinical dentistry.
- Large language models (LLMs) like ChatGPT demonstrate potential for enhancing clinical reasoning.
- Prosthodontics, with its complexity, requires careful evaluation of AI technologies.
Purpose of the Study:
- To systematically review the clinical performance of ChatGPT in prosthodontics.
- To assess ChatGPT's accuracy in diagnosis, treatment planning, and decision-making within prosthodontics.
- To critically examine the capabilities and limitations of ChatGPT in this specialized dental field.
Main Methods:
- Systematic literature search conducted in PubMed, Scopus, Web of Science, and Cochrane Library (Jan 2022 - Aug 2025).
- Inclusion of original research evaluating ChatGPT in prosthodontic contexts, employing observational, experimental, and case-based designs.
- Data extraction and synthesis guided by ENTREQ and PRISMA guidelines for transparency.
Main Results:
- ChatGPT-4 showed superior coherence, clinical relevance, and reasoning compared to earlier versions.
- Applications included implant prosthesis planning, occlusal analysis, and shade selection, with Chain-of-Thought prompting improving accuracy.
- Moderate to high response reliability was reported, but limitations include variability in complex cases and simulation-based study designs.
Conclusions:
- ChatGPT shows potential as a supplementary tool in prosthodontics, especially for education and preliminary reasoning.
- Direct clinical application necessitates caution, professional oversight, and further empirical validation.
- Future research should focus on standardized protocols and regulatory frameworks for safe AI integration.
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