Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Cell Adhesion Molecules - Types and Functions

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved in a...

PI3K/mTOR/AKT Signaling Pathway

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a rapamycin-insensitive companion...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

Adaptive Mechanisms in Cancer Cells

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hospitalized pediatric drowning in Zhejiang, China (2010-2021): an epidemiological analysis.

BMC pediatrics·2026

Same author

Enhanced Yield of <i>GmJAG1</i>-Edited Soybeans Accompanied by Improved Function of the Rhizosphere Microbiome.

Plants (Basel, Switzerland)·2026

Same author

Astrocyte-derived IL-17A facilitates angiogenesis following ischemia-like injury via an IL-6-dependent STAT3-VEGF signaling cascade.

Behavioral and brain functions : BBF·2026

Same author

Sestrin2 Mitigates Neuronal Ferroptosis Following Subarachnoid Hemorrhage via Orchestration of the AMPK/PGC1α/Nrf2 Signaling Axis.

CNS neuroscience & therapeutics·2026

Same author

Copper homeostasis dysregulation and cuproptosis in respiratory diseases.

Experimental lung research·2026

Same author

Exogenous Methyl Jasmonate Promotes Triterpene Accumulation in Loquat Callus.

Foods (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

Adiponectin and breast cancer.

Xiuping Chen¹, Yitao Wang

¹Institute of Chinese Medical Sciences, University of Macau, Av. Padre Tomas Pereira S.J., Taipa, Macau, China. xpchen@umac.mo

Medical Oncology (Northwood, London, England)

|July 14, 2010

Summary

Adiponectin, an obesity-related hormone, may influence breast cancer development. While studies show potential therapeutic benefits and tumor suppression, its exact role remains debated, requiring further research.

Area of Science:

Endocrinology
Oncology
Molecular Biology

Background:

Adiponectin, a hormone from adipose tissue, possesses anti-inflammatory, anti-atherogenic, and anti-diabetic effects.
Emerging research indicates adiponectin's involvement in the development and progression of cancers, particularly obesity-related types.

Purpose of the Study:

To review the potential role of adiponectin in breast cancer, focusing on obesity- and endocrine-associated aspects.
To explore adiponectin's expression, epidemiological associations, and therapeutic potential in breast cancer models.

Main Methods:

Review of epidemiological studies on plasma adiponectin levels and breast cancer risk.
Analysis of adiponectin and receptor expression in breast cancer cell lines and tissues.
Examination of studies investigating exogenous adiponectin's effects in animal models.

More Related Videos

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

Published on: August 23, 2018

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Published on: January 24, 2025

Related Experiment Videos

Last Updated: Jun 11, 2026

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

Published on: August 23, 2018

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Published on: January 24, 2025

Main Results:

Epidemiological data suggests plasma adiponectin levels are a risk factor for breast cancer in post-menopausal women.
Adiponectin and its receptors are expressed in breast cancer cells and tumors.
Exogenous adiponectin demonstrated therapeutic potential in animal models by inhibiting proliferation, promoting apoptosis, regulating tumorigenic factors, and suppressing angiogenesis.

Conclusions:

Adiponectin signaling pathways may offer future drug targets for breast cancer.
Further research is necessary to definitively establish adiponectin's precise role in breast cancer, as findings are currently controversial.