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A novel host-specific restriction system associated with DNA backbone S-modification in Salmonella

Tiegang Xu1, Fen Yao, Xiufen Zhou

  • 1Laboratory of Microbial Metabolism, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China.

Nucleic Acids Research
|July 15, 2010
PubMed
Summary

Scientists discovered a new DNA modification called phosphorothioation in Salmonella. This modification protects bacteria from restriction by other bacteria, enabling genetic manipulation.

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