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Published on: May 17, 2019
Mucoepidermoid carcinoma of the parotid gland: factors affecting outcome
Sarbani Ghosh-Laskar1, Vedang Murthy, Tabassum Wadasadawala
1Department of Radiation Oncology, Tata Memorial Hospital, Parel (East), Mumbai 400012, India. sarbanilaskar@yahoo.co.in
Background:
The purpose of this study was to identify the prognostic factors affecting the outcome in patients with mucoepidermoid carcinoma (MEC) of the parotid gland.
Methods:
A total of 113 patients with MEC who were treated between 1993 and 2002 were analyzed.
Results:
At median follow-up of 49 months (range, 1-143 months), disease-free survival (DFS) at 5 and 10 years was 84.6 and 84.6%, 80.7% and 67.3%, and 52.5% and 35.0% for low-grade, intermediate-grade, and high-grade tumors, respectively. Five-year and 10-year overall survival was 96.8% for low-grade tumors; 94.1% and 82.4%, respectively, for intermediate-grade tumors; and 73.3% for high-grade tumors. High-grade tumors and lymph node cancer-positive neck tumors strongly predicted poor locoregional control and DFS, while close or positive cut margins showed a trend toward poorer outcomes.
Conclusion:
Histologic grade is the most important factor affecting outcome in parotid MEC. Adjuvant radiotherapy is recommended for high-grade tumors and should be tailored according to the expected risk of recurrence for low-grade and intermediate-grade tumors.