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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Dysbiosis of the Gut Microbiota01:18

Dysbiosis of the Gut Microbiota

The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...

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Related Experiment Video

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Investigating Intestinal Inflammation in DSS-induced Model of IBD
08:43

Investigating Intestinal Inflammation in DSS-induced Model of IBD

Published on: February 1, 2012

Using metabolomic analysis to understand inflammatory bowel diseases.

Hui-Ming Lin1, Nuala A Helsby, Daryl D Rowan

  • 1School of Medical Sciences, University of Auckland, Auckland, New Zealand.

Inflammatory Bowel Diseases
|July 15, 2010
PubMed
Summary

Inflammatory bowel diseases (IBD), like Crohn's disease and ulcerative colitis, involve immune system issues and environmental factors. Metabolomic analysis helps identify disease-related metabolite changes for better understanding and treatment.

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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
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Last Updated: Jun 11, 2026

Investigating Intestinal Inflammation in DSS-induced Model of IBD
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DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
09:04

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat

Published on: February 27, 2014

Area of Science:

  • Gastroenterology and Immunology
  • Biomedical Science
  • Metabolomics

Background:

  • Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), stem from an aberrant immune response to gut microbiota.
  • The precise etiology of IBD remains elusive, influenced by genetic predispositions and environmental factors.
  • Metabolomic analysis offers a powerful tool for high-throughput measurement of metabolites in biological samples, aiding disease research.

Purpose of the Study:

  • To summarize the current understanding of IBD pathogenesis.
  • To explore the applications of metabolomic analysis in IBD research.
  • To highlight how metabolomics can improve IBD diagnosis and therapy.

Main Methods:

  • Review of current literature on IBD.
  • Analysis of previous studies utilizing metabolomic approaches in IBD.
  • Identification of metabolite perturbations associated with IBD.

Main Results:

  • Metabolomic analysis has revealed significant metabolite alterations in IBD patients.
  • These alterations provide insights into the complex pathogenesis of IBD.
  • Metabolomics shows promise for identifying novel therapeutic targets.

Conclusions:

  • Metabolomic analysis is a valuable tool for elucidating IBD pathogenesis.
  • Understanding metabolite profiles can lead to improved diagnostic and therapeutic strategies for IBD.
  • Further research integrating metabolomics is crucial for advancing IBD care.