Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 11, 2026

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

Surgery for multiple endocrine neoplasia type 1-associated primary hyperparathyroidism.

J Waldmann¹, C L López, P Langer

¹Department of Visceral, Thoracic and Vascular Surgery, University Hospital Giessen and Marburg, Marburg, Germany. jwaldman@med.uni-marburg.de

The British Journal of Surgery

|July 15, 2010

Summary

For multiple endocrine neoplasia type 1 (MEN1)-associated primary hyperparathyroidism (pHPT), total parathyroidectomy with autotransplantation (TPTX + AT) and subtotal parathyroidectomy (SPTX) offer comparable outcomes. Selective gland excision leads to higher recurrence rates.

Related Concept Videos

The Parathyroid Glands

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Controversies in NEN: An ENETS position statement on the management of locally advanced neuroendocrine neoplasia of the small intestine and pancreas without distant metastases.

Journal of neuroendocrinology·2025

Same author

Short-acting urapidil compared to long-acting phenoxybenzamine in the management of pheochromocytoma.

Langenbeck's archives of surgery·2025

Same author

[Gastroenteropancreatic neuroendocrine neoplasms-Surgery in a multimodal concept].

Chirurgie (Heidelberg, Germany)·2024

Same author

Changes in diagnosis and operative treatment of insulinoma over two decades.

Langenbeck's archives of surgery·2023

Same author

Mutation-based, short-term "neoadjuvant" treatment allows resectability in stage IVB and C anaplastic thyroid cancer.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·2023

Same author

Perioperative or only adjuvant gemcitabine plus nab-paclitaxel for resectable pancreatic cancer (NEONAX)-a randomized phase II trial of the AIO pancreatic cancer group.

Annals of oncology : official journal of the European Society for Medical Oncology·2022

Area of Science:

Endocrinology
Surgical Oncology
Genetics

Background:

Multiple endocrine neoplasia type 1 (MEN1) causes complex primary hyperparathyroidism (pHPT) due to asymmetrical hyperplasia.
Optimal surgical management for long-term normocalcemia in MEN1-associated pHPT remains debated.

Purpose of the Study:

To compare the long-term efficacy of different surgical procedures for MEN1-associated primary hyperparathyroidism.

Main Methods:

Retrospective analysis of a prospective database of patients with genetically confirmed MEN1-associated pHPT who underwent surgery between 1987 and 2009.
Evaluation of clinical data, operative procedures (total parathyroidectomy with autotransplantation, subtotal parathyroidectomy, selective gland excision), and patient outcomes.

Main Results:

Related Experiment Videos

Last Updated: Jun 11, 2026

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Transoral Endoscopic Thyroidectomy Vestibular Approach for Thyroid Lobectomy

Published on: May 12, 2023

Total parathyroidectomy with autotransplantation (TPTX + AT) had low rates of persistent (4%) and recurrent (4%) disease, with 22% permanent hypoparathyroidism.
Subtotal parathyroidectomy (SPTX) showed no persistent disease, 18% recurrence, and 45% permanent hypoparathyroidism; these rates were not significantly different from TPTX + AT.
Selective gland excision (SGE) resulted in 23% persistent disease and a significantly higher recurrence rate (46%) compared to TPTX + AT and SPTX.

Conclusions:

Both TPTX + AT and SPTX are effective surgical options for MEN1-associated pHPT, demonstrating similar recurrence rates.
SGE is associated with a higher risk of disease recurrence in MEN1-associated pHPT patients.