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Baroreflex function in chronically stressed borderline hypertensive rats.

J E Lawler1, B J Sanders, R H Cox

  • 1Physiology Program, University of Tennessee, Knoxville 37996-0900.

Physiology & Behavior
|March 1, 1991
PubMed
Summary
This summary is machine-generated.

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Chronic stress significantly impairs baroreflex function in borderline hypertensive rats, altering set point and reducing gain. This suggests stress impacts cardiovascular regulation and may contribute to hypertension development.

Area of Science:

  • Cardiovascular Physiology
  • Neuroscience
  • Stress Research

Background:

  • Baroreflex function is known to be altered during hypertension development.
  • Previous research has not investigated the impact of chronic stress on resting baroreflex function.

Purpose of the Study:

  • To determine if chronic stress alters baroreflex function in male borderline hypertensive rats (BHR) at rest.
  • To investigate the effects of varying durations of daily stress exposure on baroreflex parameters.

Main Methods:

  • Male BHR were divided into control, 5-week stressed, and 11-week stressed groups.
  • Angiotensin II (AII) was administered intravenously to elicit blood pressure and heart rate (interbeat interval, IBI) responses.
  • Intercorrelations between pressure and IBI were analyzed, and set point and gain were calculated.

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Main Results:

  • Higher AII dosages were needed to correlate pressure and IBI in stressed groups compared to controls.
  • The 5-week stress group showed a shift in baroreflex set point.
  • The 11-week stress group exhibited both a shift in set point and reduced baroreflex gain.

Conclusions:

  • Chronic stress significantly impairs baroreflex function in BHR.
  • Stress-induced alterations in baroreflex set point and gain resemble those seen in other hypertension models.
  • The central nervous system may play a crucial role in stress-mediated baroreflex dysfunction.