Related Experiment Video

Updated: Jun 11, 2026

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
08:13

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization

Published on: December 3, 2020

Ascorbic acid infusion blunts CD40L upregulation in patients undergoing coronary stent

Pasquale Pignatelli1, Gaetano Tanzilli, Roberto Carnevale

  • 1Prima Clinica Medica-Department of Experimental Medicine, University of Rome La Sapienza, Rome, Italy.

Cardiovascular Therapeutics
|July 16, 2010
PubMed

Insights

Ascorbic acid infusion effectively reduced oxidative stress and CD40L upregulation during coronary stenting. This antioxidant intervention offers a promising strategy to mitigate vascular event risks post-procedure.

Area of Science:

  • Cardiology
  • Biochemistry
  • Vascular Biology

Background:

  • CD40L upregulation post-coronary percutaneous coronary intervention is linked to vascular events.
  • The precise mechanism driving CD40L upregulation remains unclear.

Purpose of the Study:

  • To investigate the potential of ascorbic acid to reduce oxidative stress and CD40L upregulation during stenting.
  • To explore the role of oxidative stress in CD40L upregulation in this context.

Main Methods:

  • A randomized trial involving 56 patients undergoing elective coronary stenting.
  • Intravenous ascorbic acid or placebo infusion was administered.
  • Measurements included platelet CD40L, soluble CD40L, and 8-hydroxy-2'-deoxyguanosine (oxidative stress marker) pre- and post-stenting, with in vitro studies on platelet response to anoxia-reoxygenation.

Main Results:

  • Placebo group showed increased platelet CD40L, soluble CD40L, and oxidative stress markers.
  • Ascorbic acid group exhibited no change in soluble CD40L or platelet CD40L but a decrease in oxidative stress markers.
  • Ascorbic acid significantly lowered soluble CD40L, platelet CD40L, and oxidative stress markers compared to placebo.
  • In vitro, ascorbic acid inhibited reactive oxidant species and CD40L upregulation in platelets exposed to anoxia-reoxygenation.

Conclusions:

  • Coronary stenting leads to CD40L upregulation.
  • Oxidative stress is a likely mediator of this CD40L upregulation.
  • Ascorbic acid demonstrates potential in mitigating these procedural effects.
Abstract

More Related Videos

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Related Concept Videos

Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...