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Published on: March 14, 2017
Mediators of anemia in chronic heart failure
Thierry H Le Jemtel1, Salman Arain
1Tulane Heart and Vascular Institute, Tulane University School of Medicine, 1340 Tulane Avenue, SL-48, New Orleans, LA 70112, USA. lejemtel@tulane.edu
Abstract:
Anemia is highly prevalent in patients with chronic heart failure (CHF) and is associated with poor clinical outcome. Increased prevalence of anemia in CHF has been linked to advanced age, female gender, renal function impairment, severity of symptoms, and clinical settings. Overall, the anemia of CHF shares many common features with the anemia of chronic disease. Both impaired iron metabolism and inflammatory stress appear to be the key mediators of the anemia of CHF.
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