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Updated: Aug 14, 2026

Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
[Antibiotherapy of maternal-fetal infections]
1Hôpital Debrousse, Lyon.
Insights
Initial antibiotic treatment for neonatal infections targets common pathogens like Streptococcus B, E. coli, and Listeria. Prompt therapy should cover potential meningitis, with early de-escalation based on culture results for optimal outcomes.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Pharmacology
Abstract:
The initial antibiotic therapy of neonatal infections must be aimed at Streptococcus B, E. coli and Listeria which are the most frequent responsible pathogens. It must be initiated promptly and be effective against a possible meningeal infection. The first-line therapy with amoxicillin, amikacin and cefotaxime, which in theory should cover all the micro-organisms involved, must be short and rapidly replaced by an antibiotic proved to be active against the isolated pathogen. If aminoglycosides are administered for a long time, serum level assays are recommended for optimal safety.
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