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Updated: Jun 10, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Post-stroke depression: the case for augmented, individually tailored cognitive behavioural therapy.

Niall M Broomfield¹, Ken Laidlaw, Emma Hickabottom

¹Department of Clinical Health Psychology, Western Infirmary General, Glasgow and Department of Psychological Medicine, University of Glasgow, Scotland, UK. Niall.Broomfield@ggc.scot.nhs.uk

Clinical Psychology & Psychotherapy

|July 16, 2010

Summary

Post-stroke depression (PSD) is common. Cognitive behavioural therapy (CBT) shows promise but requires tailored approaches for effective treatment of depression after stroke.

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Last Updated: Jun 10, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Area of Science:

Neurology
Psychiatry
Clinical Psychology

Background:

Post-stroke depression (PSD) is a significant and prevalent complication following cerebrovascular accidents.
Understanding the underlying mechanisms and contributing factors to PSD is crucial for developing effective interventions.

Purpose of the Study:

To review the prevalence and contributing factors of post-stroke depression (PSD).
To evaluate the current evidence for cognitive behavioural therapy (CBT) in treating PSD.
To propose an augmented, individually tailored CBT protocol to improve treatment outcomes.

Main Methods:

Literature review of studies on PSD prevalence and CBT efficacy.
Analysis of existing evidence regarding the application of CBT for PSD.
Development of a novel, augmented CBT protocol based on theoretical rationale.

Main Results:

Current evidence for CBT in PSD is limited, indicating a need for further research.
There is a strong theoretical basis for CBT's effectiveness in managing PSD.
A novel augmented CBT protocol with five key components is proposed.

Conclusions:

Cognitive behavioural therapy (CBT) holds potential for treating post-stroke depression (PSD).
Augmenting and individualizing CBT is essential for maximizing its effectiveness in PSD patients.
Further research, including randomized controlled trials, is needed to validate the proposed enhanced CBT protocol for PSD.