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Updated: Jun 10, 2026

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR
Published on: February 5, 2018
Association of E-cadherin (CDH1) gene polymorphisms and gastric cancer risk
Mansour S Al-Moundhri1, Manal Al-Khanbashi, Mohammed Al-Kindi
1Medical Oncology Unit, Department of Medicine, College of Medicine and Health Sciences, Sultan Qaboos University, PO Box 35, Muscat 123, Sultanate of Oman. mansours@squ.edu.om
Aim:
To investigate the associations between CDH1 gene polymorphisms and gastric cancer (GC) risk predisposition.
Methods:
We analyzed four CDH1 polymorphisms (+54 T>C, -160 C>A, -616 G>C, -3159 T>C) in an Omani population, by extraction of genomic DNA from the peripheral blood of 192 patients with GC and 170 control participants and performed CDH1 genotyping using DNA sequencing.
Results:
CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). There was no significant association between the other polymorphisms and GC risk. The haplotype analysis of +54 T>C, -160 C>A, -616 G>C, -3159 T>C genotypes revealed that the OR of CCGC and CAGC haplotypes was 1.5 (95% CI: 0.7-3.5) and 1.5 (95% CI: 0.2-3.0), but did not reach statistical significance.
Conclusion:
The current study suggests that the -160 AA genotype was associated with an increased risk of GC in Oman.
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