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Effects of EDTA on End-Point Detection Methods

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Related Experiment Video

Updated: Jun 10, 2026

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities
06:51

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Published on: February 20, 2021

Catching errors with in vivo EPID dosimetry.

A Mans1, M Wendling, L N McDermott

  • 1Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. a.mans@nki.nl

Medical Physics
|July 17, 2010
PubMed
Summary
This summary is machine-generated.

In vivo dosimetry using electronic portal imaging devices (EPID) is crucial for radiotherapy accuracy. This method detected significant errors, including underdosage, that pretreatment verification would miss, improving patient safety.

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Last Updated: Jun 10, 2026

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Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

Published on: September 4, 2017

Area of Science:

  • Radiation Oncology
  • Medical Physics
  • Radiotherapy Quality Assurance

Background:

  • Increasing complexity of radiotherapy treatments necessitates accurate dosimetric verification.
  • Potential for detrimental incidents underscores the need for robust quality assurance methods.
  • Electronic Portal Imaging Device (EPID) dosimetry offers a solution for real-time verification.

Purpose of the Study:

  • To evaluate the effectiveness of in vivo EPID dosimetry for detecting errors in radiotherapy treatment plans.
  • To assess the clinical impact of detected dosimetric errors.
  • To highlight the importance of in vivo verification beyond pretreatment checks.

Main Methods:

  • Implementation of in vivo EPID dosimetry for all curative radiotherapy treatments.
  • Verification of 4337 patient treatment plans between January 2005 and August 2009.
  • Detailed case study of a plan transfer error in intensity-modulated radiotherapy (IMRT) for rectal cancer.

Main Results:

  • Seventeen serious errors requiring intervention were detected among 4337 verified plans.
  • Nine errors would have been missed by pretreatment verification alone.
  • A case study revealed a plan transfer error causing significant underdosage (average 11.6%, up to 20%) in the planning target volume.

Conclusions:

  • In vivo EPID dosimetry is essential for ensuring accurate radiotherapy delivery and patient safety.
  • The method effectively detects critical errors, including those missed by pretreatment verification.
  • EPID dosimetry provides a reliable means to assess the dosimetric impact of treatment deviations.