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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

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An Overview of Real-World Data Infrastructure for Cancer Research.

G Price¹, N Peek², I Eleftheriou³

¹Division of Cancer Sciences, University of Manchester, Manchester, UK; The Christie NHS Foundation Trust, Manchester, UK.

Clinical Oncology (Royal College of Radiologists (Great Britain))

|April 17, 2024

Summary

This summary is machine-generated.

Accessing real-world data (RWD) for cancer research is becoming more feasible. This paper explores RWD resources and access methods, highlighting case studies to fill evidence gaps in oncology.

Keywords:

Federated learning Real-World Data national registry secure data environment trusted research environment

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Area of Science:

Oncology
Health Informatics
Data Science

Background:

Growing interest in Real World Data (RWD) for evidence generation where clinical trial data is lacking.
Data accessibility is a significant barrier to RWD research.
RWD offers opportunities to supplement traditional research methods in oncology.

Purpose of the Study:

To discuss current Real World Data resources available for cancer research.
To outline methods for accessing these RWD sources.
To encourage further development in RWD access for oncology.

Main Methods:

Review of progress in facilitating RWD access across various scales (local, regional, national, international).
Utilized case studies, primarily from the UK, to illustrate RWD access.
Discussion of infrastructure and governance requirements for RWD utilization.

Main Results:

Significant progress has been made in RWD access over recent years.
RWD can be accessed at multiple scales, from local to international.
Case studies demonstrate practical application of RWD for research and healthcare improvement.

Conclusions:

Real-world data research is a current reality across diverse scales, despite challenges.
Effective utilization of RWD requires clear research questions and appropriate scale definition.
Addressing evidence gaps in oncology is facilitated by accessible RWD resources.