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Updated: Jun 10, 2026
Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex
Published on: August 17, 2018
Exploring the optimal site for the localization of dorsolateral prefrontal cortex in brain stimulation experiments
Paul B Fitzgerald1, Jerome J Maller, Kate E Hoy
1Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology, Psychiatry and Psychological Medicine, Melbourne, Victoria, Australia. paul.fitzgerald@med.monash.edu.au
Background:
Dorsolateral prefrontal cortex (DLPFC) is a common target for repetitive transcranial magnetic stimulation (rTMS) experiments and therapeutic protocols.
Objective:
The aim of this study was to investigate the optimal method for the localization of DLPFC for use in these studies.
Methods:
Twelve healthy subjects underwent a structural magnetic resonance imaging (MRI) scan, a TMS procedure to establish the location of the motor cortex and a neuronavigational procedure to assess the relative position of the DLPFC. Several electroencephalographic (EEG) points and a position 5 cm anterior to motor cortex were established.
Results:
The DLPFC site used was identified as being approximately halfway between the EEG points F3 and AF3. This point is considerably more anterior than the point identified by measuring 5 cm anterior to motor cortex.
Conclusions:
EEG points provide a useful way to optimally identify DLPFC.
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