Related Experiment Video
Updated: Jun 10, 2026

The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
Published on: December 19, 2025
Genetics and genomics of stroke: novel approaches
1Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York 11203, USA. alison.baird@downstate.edu
Abstract:
Evidence for a genetic basis for stroke comes from twin and family studies and from the occurrence of a number of uncommon monogenic disorders, but the contribution of genetic factors identified for stroke so far is small. Advances in genetics and genomics may permit new insights. In recent genome-wide association studies, a number of single-nucleotide polymorphisms have been associated with specific stroke subtypes and major stroke risk factors such as diabetes and atrial fibrillation. These await replication. Studies of messenger ribonucleic acid expression have also shown promise for the development of genomic signatures for stroke classification. Stroke and coronary heart disease share some features of pathophysiology, risk, and treatment, and their genetic and genomic bases also appear to overlap.
Related Concept Videos
Pharmacogenomics: Identification of New Drug Targets
Ischemic Stroke ll: Pathophysiology
Ischemic Stroke l: Introduction
Hemorrhagic Stroke ll: Pathophysiology
Hemorrhagic Stroke l: Introduction
Regulation of Stroke Volume
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...