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Updated: Jun 10, 2026
10:51
Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
Expanding horizons for nuclear receptors
Malgorzata Wiench1, Gordon L Hager
1Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
EMBO Reports
|July 17, 2010
Summary
The nuclear receptor field is advancing rapidly, with new research directions emerging. This meeting provided updates on nuclear receptor signaling, gene regulation, and their roles in cancer, development, and disease.
Area of Science:
- Molecular Biology
- Genetics
- Endocrinology
Background:
- The nuclear receptor field has evolved significantly.
- Previous meetings focused on specific nuclear receptor families ('Steroid Sisters', 'Orphan Brothers').
Purpose of the Study:
- To provide a comprehensive overview of current nuclear receptor research.
- To highlight new directions in the field, including signaling, gene regulation, cancer, development, physiology, and disease.
- To serve as an orientation for new investigators and an update for established researchers.
Main Methods:
- The content is based on presentations and discussions from the joint Keystone meetings.
- The meeting themes were 'Signalling, Gene Regulation and Cancer' and 'Development, Physiology and Disease'.
Main Results:
- The meeting showcased excellent progress in nuclear receptor research.
- New research directions are now central to the field.
- All aspects of nuclear receptor regulation were covered.
Conclusions:
- The meeting successfully updated researchers on the latest advancements in nuclear receptor biology.
- The broadened scope reflects the dynamic and expanding nature of the field.
- The event facilitated knowledge exchange for both new and experienced scientists in nuclear receptor research.
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