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Updated: Jun 10, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

Histoplasma capsulatum sinusitis: case report and review.

Marcelle D Alves¹, Lia Pinheiro, Denise Manica

¹Section of Infectious Diseases and Hematology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Ramiro Barcelos 2350, 90630-000, Porto Alegre, Brazil.

|July 17, 2010

Summary

Histoplasma capsulatum rarely causes sinusitis. This case highlights a rare instance of fungal sinusitis in a patient with chronic lymphocytic leukemia, emphasizing the need for broader differential diagnoses.

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Last Updated: Jun 10, 2026

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens

Published on: February 14, 2011

Area of Science:

Mycology
Infectious Diseases
Immunology

Background:

Histoplasma capsulatum is an endemic fungus primarily causing pulmonary infections.
Sinusitis is an uncommon presentation of histoplasmosis, particularly in immunocompetent individuals.
Chronic lymphocytic leukemia (CLL) is an underlying condition that may predispose to opportunistic infections.

Observation:

A patient with chronic lymphocytic leukemia presented with symptoms suggestive of sinusitis.
Fungal elements consistent with Histoplasma capsulatum were identified in sinus tissue.
The patient's clinical presentation and diagnostic findings confirmed H. capsulatum sinusitis.

Findings:

This case represents a rare occurrence of Histoplasma capsulatum-induced sinusitis.
The patient's immunocompromised status due to CLL likely contributed to the atypical fungal infection.
Review of literature reveals limited documented cases of H. capsulatum sinusitis.

Implications:

Clinicians should consider fungal sinusitis, including Histoplasma capsulatum, in the differential diagnosis of refractory sinusitis, especially in immunocompromised patients.
Early and accurate diagnosis of H. capsulatum sinusitis is crucial for appropriate antifungal treatment and improved patient outcomes.
This case underscores the importance of recognizing unusual fungal infections in patients with hematologic malignancies.